Canine Multiple System Degeneration (CMSD)


Please enter pet name
Please enter dog's sex
Please enter dog's date of birth
Please select if dog is KC registered
Please enter Kennel Club Name
Please enter KC Registration Number
Petagenics works very closely with the UK Kennel Club, and as such, agree to send to the Kennel Club tests results of ALL Kennel Club registered dogs, irrelevant of status (clear, carrier, affected). You (the customer), hereby agree to Petagenics forwarding your dogs test results to the Kennel Club, should you object to your dogs results being included in the results sent to the Kennel Club, then you should indicate here.
Please enter Microchip number
Please select test type
Category: Breed Title:   Breed history and information:  


Other Names:
Autosomal Recessive
4bp deletion (del TTAC)
Affected Gene(s):
Affected Breed(s):
Chinese Crested

Common Symptoms

Canine multiple system degeneration (Chinese Crested type) is a progressive inherited neurological disease affecting Chinese Crested dogs. Affected dogs present at 3 to 6 months of age with tremors, abnormal gait and poor balance. Dogs gradually progress to severe gait abnormalities, balance issues, frequent falling, abnormal body posture, abnormal eye movement and eventually are unable to move. Dogs continue to show normal mental awareness and social behavior despite movement disturbances. Most dogs die due to disease complications or are humanely euthanized by 2 years of age.


  • Johnson GS, Mhlanga-Mutangadura T, Morava E, Kozicz T, Taylor JF, O’Brien DP, Schnabel RD. Canine Multiple System Degeneration is Associated with Distinct SERAC1 Mutations in Two Different Dog Breeds [abstract]. Presented at the 63rd Annual Meeting of the American Society of Human Genetics in Boston, Massachusetts; 2013 Oct 22-26.