Familial Nephropathy (FN) (Cocker Spaniel type)

£40.00

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Petagenics works very closely with the UK Kennel Club, and as such, agree to send to the Kennel Club tests results of ALL Kennel Club registered dogs, irrelevant of status (clear, carrier, affected). You (the customer), hereby agree to Petagenics forwarding your dogs test results to the Kennel Club, should you object to your dogs results being included in the results sent to the Kennel Club, then you should indicate here.
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Description

Other Names:
Hereditary nephropathy, Nephropathy, FN, HN
Inheritance:
Autosomal Recessive
Mutation(s):
A>T
Affected Gene(s):
COL4A4
Affected Breed(s):
Australian Labradoodle, Cockapoo, Cocker Spaniel, English Cocker Spaniel, Welsh Springer Spaniel

Common Symptoms

Familial nephropathy (Cocker Spaniel type) is an inherited disorder of the kidneys affecting dogs. Dogs with this disease usually start showing symptoms of chronic kidney disease between 6 months and 2 years of age. Normally protein is not present in the urine, but in affected dogs there is a defect that allows protein from the blood to be filtered by the kidneys and lost in the urine. Abnormal amounts of protein can be detected in the urine as early as five months of age. Symptoms of chronic kidney disease include excessive thirst and urination, vomiting, inappetence, weight loss, weakness and fatigue. If drinking excessively, some dogs may also inappropriately urinate in the house or in a crate. Affected dogs eventually die of chronic kidney failure within a year.

References

  • Davidson AG, Bell RJ, Lees GE, Kashtan CE, Davidson GS, Murphy KE. Genetic cause of autosomal recessive hereditary nephropathy in the English Cocker Spaniel. J Vet Intern Med. 2007 May-Jun; 21(3):394-401. [PubMed: 17552442]
  • Lees GE, Helman RG, Kashtan CE, Michael AF, Homco LD, Millichamp NJ, Ninomiya Y, Sado Y, Naito I, Kim Y. A model of autosomal recessive Alport syndrome in English cocker spaniel dogs. Kidney Int. 1998 Sep;54(3):706-19. [PubMed: 9734596]