Familial Nephropathy (FN) (Springer Spaniel type)

£40.00

Please enter pet name
Please enter dog's sex
Please enter dog's date of birth
Please select if dog is KC registered
Please enter Kennel Club Name
Please enter KC Registration Number
Petagenics works very closely with the UK Kennel Club, and as such, agree to send to the Kennel Club tests results of ALL Kennel Club registered dogs, irrelevant of status (clear, carrier, affected). You (the customer), hereby agree to Petagenics forwarding your dogs test results to the Kennel Club, should you object to your dogs results being included in the results sent to the Kennel Club, then you should indicate here.
Please enter Microchip number
Please select test type
Category: Breed Title:   Breed history and information:  

Description

Other Names:
Hereditary nephropathy, Nephropathy, FN, HN
Inheritance:
Autosomal Recessive
Mutation(s):
C>T
Affected Gene(s):
COL4A4
Affected Breed(s):
English Springer Spaniel

Common Symptoms

Familial nephropathy (English Springer Spaniel type) is an inherited disorder of the kidneys affecting dogs. Normally protein is not present in the urine, but in affected dogs there is a defect that allows protein from the blood to be filtered by the kidneys and lost in the urine. Abnormal amounts of protein can be detected in the urine usually between 4-6 months of age. Symptoms of chronic kidney disease begin a few months after excessive protein is noted in the urine. Symptoms of chronic kidney disease include excessive thirst and urination, vomiting, inappetence, weight loss, weakness and fatigue. If drinking excessively, some dogs may also inappropriately urinate in the house or in a crate. Affected dogs typically die of chronic kidney failure by one to two years of age.

References

  • Nowend KL, Starr-Moss AN, Lees GE, Berridge BR, Clubb FJ, Kashtan CE, Nabity MB, Murphy KE. Characterization of the genetic basis for autosomal recessive hereditary nephropathy in the English Springer Spaniel. J Vet Intern Med. 2012 Mar-Apr; 26(2):294-301. [PubMed: 22369189]

acct-cart