Hereditary Nasal Parakeratosis (HNPK)

£40.00

Please enter pet name
Please enter dog's sex
Please enter dog's date of birth
Please select if dog is KC registered
Please enter Kennel Club Name
Please enter KC Registration Number
Petagenics works very closely with the UK Kennel Club, and as such, agree to send to the Kennel Club tests results of ALL Kennel Club registered dogs, irrelevant of status (clear, carrier, affected). You (the customer), hereby agree to Petagenics forwarding your dogs test results to the Kennel Club, should you object to your dogs results being included in the results sent to the Kennel Club, then you should indicate here.
Please enter Microchip number
Please select test type
Category: Breed Title:   Breed history and information:  

Description

Other Names:
HNPK
Inheritance:
Autosomal Recessive
Mutation(s):
T>G
Affected Gene(s):
SUV39H2
Affected Breed(s):
Labrador Retriever

Common Symptoms

Hereditary nasal parakeratosis is an inherited disease affecting the nose of Labrador Retrievers. Beginning around 6 to 12 months of age, affected dogs develop dry, rough, gray to brown crusts and rarely, painful cracks on the tip of the nose. In some cases, lesions are also present on the haired area around the nose. The noses of affected dogs are prone to superficial bacterial infections and often become depigmented over time. Affected dogs are otherwise healthy. Symptoms often wax and wane in severity over the dog’s life. Though manageable, this disorder requires continuous topical therapy to prevent recurrence of excessive nasal crusting.

References

  • Jagannathan V, Bannoehr J, Plattet P, Hauswirth R, Drogemuller C, Drogemuller M, Weiner DJ, Doherr M, Owczarek-Lipska M, Galichet A, Welle MM, Tengvall K, Bergvall K, Lohi H, Rufenacht S, Linek M, Paradis M, Muller EJ, Roosje P, Leeb T. A mutation in the SUV39H2 gene in Labrador retrievers with hereditary nasal parakeratosis (HNPK) provides insights into the epigenetics of keratinocyte differentiation. PLoS Genet. 2013;9(10):e1003848. doi: 10.1371/journal.pgen.1003848. Epub 2013 Oct 3. [PubMed: 24098150]
  • Page N, Paradis M, Lapointe JM, Dunstan RW. Hereditary nasal parakeratosis in Labrador Retrievers. Vet Dermatol. 2003 Apr;14(2):103-10. [PubMed: 12662268]