PRA, Progressive Cone-Rod Degeneration (PRA-prcd)

£40.00

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Petagenics works very closely with the UK Kennel Club, and as such, agree to send to the Kennel Club tests results of ALL Kennel Club registered dogs, irrelevant of status (clear, carrier, affected). You (the customer), hereby agree to Petagenics forwarding your dogs test results to the Kennel Club, should you object to your dogs results being included in the results sent to the Kennel Club, then you should indicate here.
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Description

Other Names:
PRA-PRCD, PRCD
Inheritance:
Autosomal Recessive
Mutation(s):
G>A
Affected Gene(s):
PRCD
Affected Breed(s):
American Eskimo Dog, Australian Cattle Dog, Australian Shepherd, Australian Stumpy Tail Cattle Dog, Biewer, Bolonka Zwetna, Boykin Spaniel, Chesapeake Bay Retriever, Chihuahua, Chinese Crested, Cocker Spaniel, English Cocker Spaniel, English Shepherd, Entlebucher Mountain Dog, Finnish Lapphund, Giant Schnauzer, Golden Retriever, Karelian Bear Dog, Kuvasz, Labrador Retriever, Lapponian Herder, Markiesje, Miniature American Shepherd, Miniature Australian Shepherd, Miniature Poodle, Norwegian Elkhound, Nova Scotia Duck Tolling Retriever, Poodle, Portuguese Water Dog, Rat Terrier, Russian Tsvetnaya Bolonka, Schipperke, Silky Terrier, Spanish Water Dog, Standard Poodle, Swedish Lapphund, Toy Australian Shepherd, Toy Poodle, Yorkshire Terrier

Common Symptoms

Progressive retinal atrophy, progressive rod-cone degeneration (PRA-prcd) is a late onset, inherited eye disease affecting many breeds of dog. PRA-prcd occurs as a result of degeneration of both rod and cone type photoreceptor cells of the retina, which are important for vision in dim and bright light, respectively. Evidence of retinal disease in affected dogs can first be seen on an electroretinogram around 1.5 years of age for most breeds, but most affected dogs will not show signs of vision loss until 3 to 5 years of age or later. The rod type cells are affected first and affected dogs will initially have vision deficits in dim light (night blindness) and loss of peripheral vision. Over time affected dogs continue to lose night vision and begin to show visual deficits in bright light. Other signs of progressive retinal atrophy involve changes in reflectivity and appearance of a structure behind the retina called the tapetum that can be observed on a veterinary eye exam. Although there is individual and breed variation in the age of onset and the rate of disease progression, the disease eventually progresses to complete blindness in most dogs. Other inherited disorders of the eye can appear similar to PRA-prcd. Genetic testing may help clarify if a dog is affected with PRA-prcd or another inherited condition of the eye.

References

  • Dostal J, Hrdlicova A, Horak P. Progressive rod-cone degeneration (PRCD) in selected dog breeds and variability in its phenotypic expression. Veterinarni Medicina. 2011 Jun; 56(5):243-47. [Not In PubMed]
  • Kohyama M1, Tada N, Mitsui H, Tomioka H, Tsutsui T, Yabuki A, Rahman MM, Kushida K, Mizukami K, Yamato O. Real-time PCR genotyping assay for canine progressive rod-cone degeneration and mutant allele frequency in Toy Poodles, Chihuahuas and Miniature Dachshunds in Japan. J Vet Med Sci. 2015 Nov 6. [PubMed: 26549343]
  • Moody JA, Famula TR, Sampson RC, Murphy KE. Identification of microsatellite markers linked progressive retinal atrophy in American Eskimo Dogs. Am J Vet Res. 2005 Nov;66(11):1900-2. [PubMed: 16334947]
  • Zangerl B, Goldstein O, Philp AR, Lindauer SJ, Pearce-Kelling SE, Mullins RF, Graphodatsky AS, Ripoll D, Felix JS, Stone EM, Acland GM, Aguirre GD. Identical mutation in a novel retinal gene causes progressive rod-cone degeneration in dogs and retinitis pigmentosa in humans. Genomics. 2006 Nov; 88(5):551-63. [PubMed: 16938425]