Pyruvate kinase deficiency (PKD) (Pug type)

£40.00

Please enter pet name
Please enter dog's sex
Please enter dog's date of birth
Please select if dog is KC registered
Please enter Kennel Club Name
Please enter KC Registration Number
Petagenics works very closely with the UK Kennel Club, and as such, agree to send to the Kennel Club tests results of ALL Kennel Club registered dogs, irrelevant of status (clear, carrier, affected). You (the customer), hereby agree to Petagenics forwarding your dogs test results to the Kennel Club, should you object to your dogs results being included in the results sent to the Kennel Club, then you should indicate here.
Please enter Microchip number
Please select test type
Category: Breed Title:   Breed history and information:  

Description

Other Names:
Pyruvate kinase deficiency of erythrocytes, PK deficiency
Inheritance:
Autosomal Recessive
Mutation(s):
T>C
Affected Gene(s):
PKLR
Affected Breed(s):
Carlin Pinscher, Pug

Common Symptoms

Pyruvate kinase deficiency (Pug type) is an inherited metabolic disease affecting Pugs. Affected dogs have insufficient activity of the pyruvate kinase enzyme which breaks down glycogen for energy. Deficiency of this enzyme results primarily in easily damaged red blood cells (hemolysis). Affected dogs typically present between 4 months and 2 year of age with pale gums from decreased numbers of red blood cells (anemia) and lethargy or exercise intolerance. Clinical findings during a veterinary exam include severe anemia, hardening of the bones, and an enlarged spleen and liver. While dogs can live for several years with this disease, they typically die from severe anemia or liver failure between 5 to 9 years of age.

References

No additional references